
Your Practical Solution to cGMP Compliance
Containment Barrier Isolator – Convertible Class III/Class I Biosafety Cabinet (CBI-H) builds on Esco Pharma’s success of CBI-III. It allows operators to work via a removable glove visor to convert the cabinet and function as a Class III or a Class I Biosafety Cabinet as per EN 12469 standards. In BSC Class III mode, the operator works through a glove port attached to a removable panel. It can be converted to a BSC Class I by removing the closure panel and attaching a blanking plate over the inlet HEPA filter.
To ensure maximum performance, commissioning and preventive maintenance of the cabinet must be done in both modes.
APPLICATIONS
Guide to Models
CBI-H-___-___-___-__
Isolator Unit | Model | Internal Width | No. of Gloves Ports | Voltage Code | Pressure | Airflow | NUMBER of PTC | Type of PTC | Sharps Bin inside | |||||||
Containment Barrier Isolator | CBI | Hybrid Model (Class III/Class I Convertible Biosafety Cabinet) | H | 1200mm | 2G | 220-240 VAC, 50/60 Hz | 8 | Negative | N | Single Pass/Total Exhaust | S | 1 Left | L | PTC0 to PTC7 (see PTC legend) | with sharps container provision | S |
1600mm | 3G | 1 Right | R | |||||||||||||
2000mm | 4G | 110-120 VAC, 50/60 Hz | 9 | Both Left and Right | B | without sharps container provision | 0 | |||||||||
No PTC | 0 |
LIST OF OPTIONS for CBI Models | CBI-U | CBI - T | CBI-III | CBI-H | |||
4" Split Butterfly Valve (for powder discharge of powder below isolator chamber) | ✔ | ✔ | |||||
Adjustable Hydraulic Stand (based on operator ID input) | ✔ | ✔ | ✔ | ||||
Exhaust Box (with automated dampers with inflatable seals or manual with valve) | ✔ | ✔ | ✔ | ||||
Anti-blow back damper box | ✔ | ✔ | ✔ | ||||
Automated Pressure Hold Test | with Client Supplied Compressed Air | ✔ | ✔ | ✔ | ✔ | ||
with On-board Air Compressor | ✔ | ✔ | ✔ | ✔ | |||
Bag Welder with Table Bag-out Port |
✔ | ✔ | ✔ | ||||
Bio Dunk Tank Bag Out Port |
✔ | ✔ | |||||
Mobile Biodecontamination BioVap TM | ✔ | ✔ | ✔ | ||||
Carbon Filter | ✔ | ||||||
Convertible to Class 1 cabinet | ✔ | ||||||
Integration of small scale aseptic or potent tablet/capsule etc… | ✔ | ✔ | ✔ | ✔ | |||
Double-sided access | ✔ | ✔ | ✔ | ||||
Manual Drain Ball Valve (for client controlled CIP/WP) must order with inner pass-through inflatable sealed doors. | ✔ | ✔ | |||||
Electrical Outlet (IP66) | IP 66 | ✔ | ✔ | ✔ | ✔ | ||
ATEX Zone 1/21 (only for internal environment) | ✔ | ✔ | ✔ | ||||
ATEX rating up to zone 1/21 internally only (ATEX fan, “IS” signals for internal door sensor/push button) | ✔ | ✔ | |||||
Glove Leak Tester | ✔ | ✔ | ✔ | ✔ | |||
Formalin Vaporizer (auto neutralization and purge cycle) | ✔ | ✔ | ✔ | ||||
H2O2 Monitoring (sensor is not integrated with HMI) | ✔ | ✔ | ✔ | ||||
Liquid Water Entry / Exit Ports | ✔ | ✔ | |||||
N2 Purge for Process Chamber | ✔ | ||||||
Ø250 mm Product Waste Bag Out Ports / | ✔ | ||||||
Battery option to maintain EM interlock during power outage or E Stop | ✔ | ✔ | ✔ | ✔ | |||
Particle Counter | Portable Paricle Counter (Non-viable) | ✔ | ✔ | ✔ | |||
Microbial Air Samples (Viable Particle Counter) | ✔ | ✔ | ✔ | ||||
Product Waste Entry / Exit Ports | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Alpha | ✔ | ✔ | ✔ | ✔ | |||
RTPØ 105, 190, 270 - Beta Canister | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Beta Liner | ✔ | ✔ | |||||
RTPØ 350, 460 - Alpha, Beta Liner, Beta Canister | ✔ | ✔ | ✔ | ||||
Service Fixtures (Vacuum, Nitrogen, Compressed Air, Nozzle for BioVap) | ✔ | ✔ | ✔ | ✔ | |||
Spray Ball (CIP) with Manual Ball Valve | ✔ | ||||||
Spray Gun (WIP) with Manual Ball Valve | ✔ | ✔ | |||||
Sterile Continuous Liner | ✔ | ✔ | ✔ | ||||
Sterility Test Pump | ✔ | ||||||
Temperature and Relative Humidity Monitoring (only for process chamber) | ✔ | ✔ | ✔ | ✔ | |||
Rear view monitor | ✔ | ✔ | ✔ | ✔ | |||
UV Lamp | ✔ | ✔ | |||||
Weighing Scale Granite Slab | ✔ | ✔ | ✔ | ||||
Sharps (inside) | ✔ |
EQUIPMENT INTEGRATION/ CUSTOMIZATION EXAMPLES | CBI-U | CBI - T | CBI-III | CBI-III/1 | |||
Autoclave | ✔ | ✔ | |||||
Analytical Balance | ✔ | ✔ | ✔ | ✔ | |||
Biosafety Cabinet | ✔ | ||||||
CCTV Camera | ✔ | ✔ | ✔ | ||||
CCTV Camera Provision | ✔ | ✔ | ✔ | ||||
Fume Cabinet Integration | ✔ | ||||||
Vacuum Oven / Tray Dryer integration | ✔ | ||||||
Non C02 Incubator Integration | ✔ | ✔ | ✔ | ||||
CO2 Incubator Integration | ✔ | ✔ | |||||
Centrifuge Integration | ✔ | ✔ | ✔ | ✔ | |||
Drybath Integration | ✔ | ||||||
Esco Sublimate freeze dryer | ✔ | ✔ | ✔ | ✔ | |||
Refrigerated Microcentrifuge Integration | ✔ | ||||||
3rd party Freeze dryer | ✔ | ✔ | ✔ | ✔ |
Guide to Models
CBI-H-___-___-___-__
Isolator Unit | Model | Internal Width | No. of Gloves Ports | Voltage Code | Pressure | Airflow | NUMBER of PTC | Type of PTC | Sharps Bin inside | |||||||
Containment Barrier Isolator | CBI | Hybrid Model (Class III/Class I Convertible Biosafety Cabinet) | H | 1200mm | 2G | 220-240 VAC, 50/60 Hz | 8 | Negative | N | Single Pass/Total Exhaust | S | 1 Left | L | PTC0 to PTC7 (see PTC legend) | with sharps container provision | S |
1600mm | 3G | 1 Right | R | |||||||||||||
2000mm | 4G | 110-120 VAC, 50/60 Hz | 9 | Both Left and Right | B | without sharps container provision | 0 | |||||||||
No PTC | 0 |
LIST OF OPTIONS for CBI Models | CBI-U | CBI - T | CBI-III | CBI-H | |||
4" Split Butterfly Valve (for powder discharge of powder below isolator chamber) | ✔ | ✔ | |||||
Adjustable Hydraulic Stand (based on operator ID input) | ✔ | ✔ | ✔ | ||||
Exhaust Box (with automated dampers with inflatable seals or manual with valve) | ✔ | ✔ | ✔ | ||||
Anti-blow back damper box | ✔ | ✔ | ✔ | ||||
Automated Pressure Hold Test | with Client Supplied Compressed Air | ✔ | ✔ | ✔ | ✔ | ||
with On-board Air Compressor | ✔ | ✔ | ✔ | ✔ | |||
Bag Welder with Table Bag-out Port |
✔ | ✔ | ✔ | ||||
Bio Dunk Tank Bag Out Port |
✔ | ✔ | |||||
Mobile Biodecontamination BioVap TM | ✔ | ✔ | ✔ | ||||
Carbon Filter | ✔ | ||||||
Convertible to Class 1 cabinet | ✔ | ||||||
Integration of small scale aseptic or potent tablet/capsule etc… | ✔ | ✔ | ✔ | ✔ | |||
Double-sided access | ✔ | ✔ | ✔ | ||||
Manual Drain Ball Valve (for client controlled CIP/WP) must order with inner pass-through inflatable sealed doors. | ✔ | ✔ | |||||
Electrical Outlet (IP66) | IP 66 | ✔ | ✔ | ✔ | ✔ | ||
ATEX Zone 1/21 (only for internal environment) | ✔ | ✔ | ✔ | ||||
ATEX rating up to zone 1/21 internally only (ATEX fan, “IS” signals for internal door sensor/push button) | ✔ | ✔ | |||||
Glove Leak Tester | ✔ | ✔ | ✔ | ✔ | |||
Formalin Vaporizer (auto neutralization and purge cycle) | ✔ | ✔ | ✔ | ||||
H2O2 Monitoring (sensor is not integrated with HMI) | ✔ | ✔ | ✔ | ||||
Liquid Water Entry / Exit Ports | ✔ | ✔ | |||||
N2 Purge for Process Chamber | ✔ | ||||||
Ø250 mm Product Waste Bag Out Ports / | ✔ | ||||||
Battery option to maintain EM interlock during power outage or E Stop | ✔ | ✔ | ✔ | ✔ | |||
Particle Counter | Portable Paricle Counter (Non-viable) | ✔ | ✔ | ✔ | |||
Microbial Air Samples (Viable Particle Counter) | ✔ | ✔ | ✔ | ||||
Product Waste Entry / Exit Ports | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Alpha | ✔ | ✔ | ✔ | ✔ | |||
RTPØ 105, 190, 270 - Beta Canister | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Beta Liner | ✔ | ✔ | |||||
RTPØ 350, 460 - Alpha, Beta Liner, Beta Canister | ✔ | ✔ | ✔ | ||||
Service Fixtures (Vacuum, Nitrogen, Compressed Air, Nozzle for BioVap) | ✔ | ✔ | ✔ | ✔ | |||
Spray Ball (CIP) with Manual Ball Valve | ✔ | ||||||
Spray Gun (WIP) with Manual Ball Valve | ✔ | ✔ | |||||
Sterile Continuous Liner | ✔ | ✔ | ✔ | ||||
Sterility Test Pump | ✔ | ||||||
Temperature and Relative Humidity Monitoring (only for process chamber) | ✔ | ✔ | ✔ | ✔ | |||
Rear view monitor | ✔ | ✔ | ✔ | ✔ | |||
UV Lamp | ✔ | ✔ | |||||
Weighing Scale Granite Slab | ✔ | ✔ | ✔ | ||||
Sharps (inside) | ✔ |
EQUIPMENT INTEGRATION/ CUSTOMIZATION EXAMPLES | CBI-U | CBI - T | CBI-III | CBI-III/1 | |||
Autoclave | ✔ | ✔ | |||||
Analytical Balance | ✔ | ✔ | ✔ | ✔ | |||
Biosafety Cabinet | ✔ | ||||||
CCTV Camera | ✔ | ✔ | ✔ | ||||
CCTV Camera Provision | ✔ | ✔ | ✔ | ||||
Fume Cabinet Integration | ✔ | ||||||
Vacuum Oven / Tray Dryer integration | ✔ | ||||||
Non C02 Incubator Integration | ✔ | ✔ | ✔ | ||||
CO2 Incubator Integration | ✔ | ✔ | |||||
Centrifuge Integration | ✔ | ✔ | ✔ | ✔ | |||
Drybath Integration | ✔ | ||||||
Esco Sublimate freeze dryer | ✔ | ✔ | ✔ | ✔ | |||
Refrigerated Microcentrifuge Integration | ✔ | ||||||
3rd party Freeze dryer | ✔ | ✔ | ✔ | ✔ |
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Esco Micro Pte. Ltd.
21 Changi South Street 1 Singapore 486777
+65 65420833 | +65 65426920