
Your Practical Solution to cGMP Compliance
Containment Barrier Isolator – Turbulent (CBI-T) utilizes turbulent airflow and facilitates the isolation of a product or process while providing the required condition for handling potent powder compounds.
In CBI-T, a supply filtered air is introduced into the chamber that mixes with and dilutes airborne contaminants, thus reducing the concentration within the environment. Most contaminants are ultimately removed from the environment through the air exhaust system. Contamination removal takes longer to achieve because the air turbulence keeps particles suspended and the dilution process is dependent on the volume of air cycling through the space.
APPLICATIONS
Guide to Models
CBI-T-___-___-___-__
Isolator Unit | Model | Internal Width | No. of Gloves Ports | Voltage Code | Pressure | Airflow | NUMBER of PTC | Type of PTC | Sharps Bin inside | |||||||
Containment Barrier Isolator | CBI | Turbulent | T | 1200mm | 2G | 220-240 VAC, 50/60 Hz | 8 | Negative | N | Single Pass/Total Exhaust | S | 1 Left | L | PTC0 to PTC7 (see PTC legend) | with sharps container provision | S |
1600mm | 3G | 1 Right | R | |||||||||||||
2000mm | 4G | 110-120 VAC, 50/60 Hz | 9 | Both Left and Right | B | without sharps container provision | 0 | |||||||||
No PTC | 0 |
LIST OF OPTIONS for CBI Models | CBI-U | CBI - T | CBI-III | CBI-H | |||
4" Split Butterfly Valve (for powder discharge of powder below isolator chamber) | ✔ | ✔ | |||||
Adjustable Hydraulic Stand (based on operator ID input) | ✔ | ✔ | ✔ | ||||
Exhaust Box (with automated dampers with inflatable seals or manual with valve) | ✔ | ✔ | ✔ | ||||
Anti-blow back damper box | ✔ | ✔ | ✔ | ||||
Automated Pressure Hold Test | with Client Supplied Compressed Air | ✔ | ✔ | ✔ | ✔ | ||
with On-board Air Compressor | ✔ | ✔ | ✔ | ✔ | |||
Bag Welder with Table Bag-out Port |
✔ | ✔ | ✔ | ||||
Bio Dunk Tank Bag Out Port |
✔ | ✔ | |||||
Mobile Biodecontamination BioVap TM | ✔ | ✔ | ✔ | ||||
Carbon Filter | ✔ | ||||||
Convertible to Class 1 cabinet | ✔ | ||||||
Integration of small scale aseptic or potent tablet/capsule etc… | ✔ | ✔ | ✔ | ✔ | |||
Double-sided access | ✔ | ✔ | ✔ | ||||
Manual Drain Ball Valve (for client controlled CIP/WP) must order with inner pass-through inflatable sealed doors. | ✔ | ✔ | |||||
Electrical Outlet (IP66) | IP 66 | ✔ | ✔ | ✔ | ✔ | ||
ATEX Zone 1/21 (only for internal environment) | ✔ | ✔ | ✔ | ||||
ATEX rating up to zone 1/21 internally only (ATEX fan, “IS” signals for internal door sensor/push button) | ✔ | ✔ | |||||
Glove Leak Tester | ✔ | ✔ | ✔ | ✔ | |||
Formalin Vaporizer (auto neutralization and purge cycle) | ✔ | ✔ | ✔ | ||||
H2O2 Monitoring (sensor is not integrated with HMI) | ✔ | ✔ | ✔ | ||||
Liquid Water Entry / Exit Ports | ✔ | ✔ | |||||
N2 Purge for Process Chamber | ✔ | ||||||
Ø250 mm Product Waste Bag Out Ports / | ✔ | ||||||
Battery option to maintain EM interlock during power outage or E Stop | ✔ | ✔ | ✔ | ✔ | |||
Particle Counter | Portable Paricle Counter (Non-viable) | ✔ | ✔ | ✔ | |||
Microbial Air Samples (Viable Particle Counter) | ✔ | ✔ | ✔ | ||||
Product Waste Entry / Exit Ports | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Alpha | ✔ | ✔ | ✔ | ✔ | |||
RTPØ 105, 190, 270 - Beta Canister | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Beta Liner | ✔ | ✔ | |||||
RTPØ 350, 460 - Alpha, Beta Liner, Beta Canister | ✔ | ✔ | ✔ | ||||
Service Fixtures (Vacuum, Nitrogen, Compressed Air, Nozzle for BioVap) | ✔ | ✔ | ✔ | ✔ | |||
Spray Ball (CIP) with Manual Ball Valve | ✔ | ||||||
Spray Gun (WIP) with Manual Ball Valve | ✔ | ✔ | |||||
Sterile Continuous Liner | ✔ | ✔ | ✔ | ||||
Sterility Test Pump | ✔ | ||||||
Temperature and Relative Humidity Monitoring (only for process chamber) | ✔ | ✔ | ✔ | ✔ | |||
Rear view monitor | ✔ | ✔ | ✔ | ✔ | |||
UV Lamp | ✔ | ✔ | |||||
Weighing Scale Granite Slab | ✔ | ✔ | ✔ | ||||
Sharps (inside) | ✔ |
EQUIPMENT INTEGRATION/ CUSTOMIZATION EXAMPLES | CBI-U | CBI - T | CBI-III | CBI-III/1 | |||
Autoclave | ✔ | ✔ | |||||
Analytical Balance | ✔ | ✔ | ✔ | ✔ | |||
Biosafety Cabinet | ✔ | ||||||
CCTV Camera | ✔ | ✔ | ✔ | ||||
CCTV Camera Provision | ✔ | ✔ | ✔ | ||||
Fume Cabinet Integration | ✔ | ||||||
Vacuum Oven / Tray Dryer integration | ✔ | ||||||
Non C02 Incubator Integration | ✔ | ✔ | ✔ | ||||
CO2 Incubator Integration | ✔ | ✔ | |||||
Centrifuge Integration | ✔ | ✔ | ✔ | ✔ | |||
Drybath Integration | ✔ | ||||||
Esco Sublimate freeze dryer | ✔ | ✔ | ✔ | ✔ | |||
Refrigerated Microcentrifuge Integration | ✔ | ||||||
3rd party Freeze dryer | ✔ | ✔ | ✔ | ✔ |
Guide to Models
CBI-T-___-___-___-__
Isolator Unit | Model | Internal Width | No. of Gloves Ports | Voltage Code | Pressure | Airflow | NUMBER of PTC | Type of PTC | Sharps Bin inside | |||||||
Containment Barrier Isolator | CBI | Turbulent | T | 1200mm | 2G | 220-240 VAC, 50/60 Hz | 8 | Negative | N | Single Pass/Total Exhaust | S | 1 Left | L | PTC0 to PTC7 (see PTC legend) | with sharps container provision | S |
1600mm | 3G | 1 Right | R | |||||||||||||
2000mm | 4G | 110-120 VAC, 50/60 Hz | 9 | Both Left and Right | B | without sharps container provision | 0 | |||||||||
No PTC | 0 |
LIST OF OPTIONS for CBI Models | CBI-U | CBI - T | CBI-III | CBI-H | |||
4" Split Butterfly Valve (for powder discharge of powder below isolator chamber) | ✔ | ✔ | |||||
Adjustable Hydraulic Stand (based on operator ID input) | ✔ | ✔ | ✔ | ||||
Exhaust Box (with automated dampers with inflatable seals or manual with valve) | ✔ | ✔ | ✔ | ||||
Anti-blow back damper box | ✔ | ✔ | ✔ | ||||
Automated Pressure Hold Test | with Client Supplied Compressed Air | ✔ | ✔ | ✔ | ✔ | ||
with On-board Air Compressor | ✔ | ✔ | ✔ | ✔ | |||
Bag Welder with Table Bag-out Port |
✔ | ✔ | ✔ | ||||
Bio Dunk Tank Bag Out Port |
✔ | ✔ | |||||
Mobile Biodecontamination BioVap TM | ✔ | ✔ | ✔ | ||||
Carbon Filter | ✔ | ||||||
Convertible to Class 1 cabinet | ✔ | ||||||
Integration of small scale aseptic or potent tablet/capsule etc… | ✔ | ✔ | ✔ | ✔ | |||
Double-sided access | ✔ | ✔ | ✔ | ||||
Manual Drain Ball Valve (for client controlled CIP/WP) must order with inner pass-through inflatable sealed doors. | ✔ | ✔ | |||||
Electrical Outlet (IP66) | IP 66 | ✔ | ✔ | ✔ | ✔ | ||
ATEX Zone 1/21 (only for internal environment) | ✔ | ✔ | ✔ | ||||
ATEX rating up to zone 1/21 internally only (ATEX fan, “IS” signals for internal door sensor/push button) | ✔ | ✔ | |||||
Glove Leak Tester | ✔ | ✔ | ✔ | ✔ | |||
Formalin Vaporizer (auto neutralization and purge cycle) | ✔ | ✔ | ✔ | ||||
H2O2 Monitoring (sensor is not integrated with HMI) | ✔ | ✔ | ✔ | ||||
Liquid Water Entry / Exit Ports | ✔ | ✔ | |||||
N2 Purge for Process Chamber | ✔ | ||||||
Ø250 mm Product Waste Bag Out Ports / | ✔ | ||||||
Battery option to maintain EM interlock during power outage or E Stop | ✔ | ✔ | ✔ | ✔ | |||
Particle Counter | Portable Paricle Counter (Non-viable) | ✔ | ✔ | ✔ | |||
Microbial Air Samples (Viable Particle Counter) | ✔ | ✔ | ✔ | ||||
Product Waste Entry / Exit Ports | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Alpha | ✔ | ✔ | ✔ | ✔ | |||
RTPØ 105, 190, 270 - Beta Canister | ✔ | ✔ | |||||
RTPØ 105, 190, 270 - Beta Liner | ✔ | ✔ | |||||
RTPØ 350, 460 - Alpha, Beta Liner, Beta Canister | ✔ | ✔ | ✔ | ||||
Service Fixtures (Vacuum, Nitrogen, Compressed Air, Nozzle for BioVap) | ✔ | ✔ | ✔ | ✔ | |||
Spray Ball (CIP) with Manual Ball Valve | ✔ | ||||||
Spray Gun (WIP) with Manual Ball Valve | ✔ | ✔ | |||||
Sterile Continuous Liner | ✔ | ✔ | ✔ | ||||
Sterility Test Pump | ✔ | ||||||
Temperature and Relative Humidity Monitoring (only for process chamber) | ✔ | ✔ | ✔ | ✔ | |||
Rear view monitor | ✔ | ✔ | ✔ | ✔ | |||
UV Lamp | ✔ | ✔ | |||||
Weighing Scale Granite Slab | ✔ | ✔ | ✔ | ||||
Sharps (inside) | ✔ |
EQUIPMENT INTEGRATION/ CUSTOMIZATION EXAMPLES | CBI-U | CBI - T | CBI-III | CBI-III/1 | |||
Autoclave | ✔ | ✔ | |||||
Analytical Balance | ✔ | ✔ | ✔ | ✔ | |||
Biosafety Cabinet | ✔ | ||||||
CCTV Camera | ✔ | ✔ | ✔ | ||||
CCTV Camera Provision | ✔ | ✔ | ✔ | ||||
Fume Cabinet Integration | ✔ | ||||||
Vacuum Oven / Tray Dryer integration | ✔ | ||||||
Non C02 Incubator Integration | ✔ | ✔ | ✔ | ||||
CO2 Incubator Integration | ✔ | ✔ | |||||
Centrifuge Integration | ✔ | ✔ | ✔ | ✔ | |||
Drybath Integration | ✔ | ||||||
Esco Sublimate freeze dryer | ✔ | ✔ | ✔ | ✔ | |||
Refrigerated Microcentrifuge Integration | ✔ | ||||||
3rd party Freeze dryer | ✔ | ✔ | ✔ | ✔ |
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Esco Micro Pte. Ltd.
21 Changi South Street 1 Singapore 486777
+65 65420833 | +65 65426920